Tolerogenic vaccines: Targeting the antigenic and cytokine niches of FOXP3+ regulatory T cells

Mark D. Mannie,Kayla B. DeOca, Alexander G. Bastian,Cody D. Moorman

Cellular Immunology（2020）

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摘要

•TCR recognition efficiencies shape the repertoire of CD4+ CD25high FOXP3+ regulatory T cells.•The Treg antigenic niche controls tissue-residency, stability, and regulatory function in peripheral tissues.•Tolerogenic vaccination and Treg-based immunotherapy reverse chronic autoimmune disease.•Tregs mediate tolerance by mechanisms of bystander suppression and infectious tolerance.•Intermediate-efficiency MHC-ligands, high-zone IFN-β, and low-zone IL-2 favor Treg responses.

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关键词

APC,CNS,CFA,Tcon,DC,EAE,FOXP3,FOXP3+,GM-CSF,IFN-β,IL-2,CD25 or IL2Rα,MHC,MHCI or MHCII,MBP,MOG,MS,NAg,NFM,OVA,PLP,TCR

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