A 96-Monolithic inorganic hollow fiber array as a new geometry for high throughput solid-phase microextraction of doxorubicin in water and human urine samples coupled with liquid chromatography–tandem mass spectrometry

•An innovative configuration was developed for high-throughput SPME approach.•A new-design inorganic HAP/TiO2 hollow fiber with PVA modification was introduced.•Doxorubicin quantification by SPME was reported for the first time in urine media.•Biocompatibility of sorbent offers multi target monitoring in biological matrices.•Better method validation data were obtained in comparison with related techniques.