Prostaglandins prevent acetaminophen induced embryo toxicity in zebrafish (Danio rerio).

Michal Galus,Shamaila Fraz,Akash Gugilla,Maria Jönsson,Joanna Y Wilson

Environmental Toxicology and Pharmacology（2020）

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摘要

•ACE exposure of zebrafish embryos leads to higher abnormality and mortality.•ACE disrupts the COX-PG pathway in early developing zebrafish embryos.•MOA of ACE in zebrafish embryos is similar to therapeutic effects in mammals.

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关键词

CTL,ACE,PG,COX,NSAIDs,hpf

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