RETRACTED: Enhanced Polyubiquitination of Shank3 and NMDA Receptor in a Mouse Model of Autism

M Ali Bangash,Joo Min Park,Tatiana Melnikova,Dehua Wang, Soo Kyeong Jeon, Deidre Lee, Sbaa Syeda, Juno Kim,Mehreen Kouser, Joshua Schwartz,Yiyuan Cui,Xia Zhao,Haley E. Speed, Sara E. Kee, Jian Cheng Tu,Jia-Hua Hu,Ronald S. Petralia,David J. Linden,Craig M. Powell, Alena Savonenko

Cell(2011)

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摘要
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).This article has been retracted at the request of the Authors.Our paper reported an analysis of a mouse genetic model that deletes the C terminus of Shank3 to mimic human mutations that cause autism spectrum disorder. Figure panels for several polyubiquitination assays were improperly assembled, leading to multiple repetitions of bands in western blots of the lysates. These errors did not affect the quantitative analysis of polyubiquitination because this analysis was performed as described and was not dependent on representative western blot images. In light of the figure preparation issues, we feel that the most responsible course of action is to retract the paper. We sincerely apologize to the scientific community for any misunderstanding that these errors may have caused.
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