In vitro study of aripiprazole loading and releasing efficiency of SBA-16

Mesoporous silica (SBA-16) was synthesized by the hydrothermal synthesis route. The structural properties of the synthesized SBA-16 were found out by a small-angle X-ray diffraction technique. Morphological characterization was characterized by scanning electron microscope (SEM) and high-resolution transmission electron microscope (HRTEM). Nitrogen adsorption–desorption isotherm was used to find out surface area, pore size, and pore volume. Aripiprazole was used as a model drug to calculate drug loading efficiency of prepared SBA-16 and their release kinetics was also calculated with the response to three different pH solutions. UV–Visible spectrophotometer was used to find out the absorbance of the sample. The results indicated that the synthesized SBA-16 has high drug loading efficiency with a control release profile.