Does empagliflozin modulate the autonomic nervous system among individuals with type 2 diabetes and coronary artery disease? The EMPA-HEART CardioLink-6 Holter analysis.

•Sodium-glucose cotransporter-2 (SGLT2) inhibitors’ mechanism of cardiovascular benefit is unknown.•Impaired autonomic tone is associated with adverse cardiac events.•Cardiac autonomic tone was assessed with Holter studies from a randomized trial.•Similar autonomic tone noted between subjects treated with empagliflozin and placebo.