Metabonomics reveals altered metabolites related to inflammation and energy utilization at recovery of cystic fibrosis lung exacerbation.

•Serum metabonomics distinguishes cystic fibrosis exacerbation to resolution state.•Distinguishing pathways indicate alterations in (gut) microbiome and bile acids.•Serum metabolites at resolution show decreased inflammation and oxidative stress.•Lipid markers indicate improvement from a catabolic state at exacerbation.