In vitro antibacterial activity of ceftazidime/avibactam in combination against planktonic and biofilm carbapenemase-producing Klebsiella pneumoniae isolated from blood

Papalini Chiara,Sabbatini Samuele,Monari Claudia,Mencacci Antonella,Francisci Daniela,Perito Stefano,Pasticci Maria Bruna

Journal of Global Antimicrobial Resistance（2020）

引用 4|浏览25

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摘要

•Between 2014 and 2019, a total of 4241 blood cultures resulted positive.•From 4241 blood samples, 130 (3.1%) KPC-producing K. pneumoniae (KPC-Kp) were identified.•More than 96% of KPC-Kp isolates were resistant to meropenem.•Ceftazidime/avibactam+meropenem showed synergistic or additive antibacterial activity.

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关键词

Klebsiella pneumoniae,Biofilm,Carbapenemase,Ceftazidime/avibactam,Synergism

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