Relationships Between Memory Decline And The Use Of Metformin Or Dpp4 Inhibitors In People With Type 2 Diabetes With Normal Cognition Or Alzheimer'S Disease, And The Role Apoe Carrier Status
ALZHEIMERS & DEMENTIA(2020)
摘要
Introduction: Few studies have examined memory decline among patients with type 2 diabetes using different oral hypoglycemic drugs.Methods: Participants with normal cognition (NC) or Alzheimer's disease (AD) dementia using a hypoglycemic medication (2005 to 2019) were identified from the National Alzheimer's Coordinating Center database. Delayed memory was assessed using the Wechsler Memory Scale Revised-Logical Memory test. Associations between oral drug classes and memory over time were examined using mixed-effects models with inverse probability treatment weights.Results: In NC (n = 1192), metformin use was associated with better memory performance over time, whereas in AD (n = 807), dipeptidyl peptidase-4 (DPP4) inhibitor use was associated with a slower rate of memory decline. Interaction effects suggested greater benefit associated with DPP4 inhibitor use among APOE epsilon 4 carriers.Discussion: Associations between different oral hypoglycemic drugs and memory change were not consistent between cognitively normal elderly and those with AD dementia. APOE epsilon 4 genotype modified some relationships.
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关键词
Alzheimer's disease (AD), apolipoprotein E (APOE), diabetes, dipeptidyl peptidase-4 inhibitor (DPP4 inhibitor), memory, metformin, sulfonylurea, thiazolidinedione
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