Selenium-independent antioxidant and anti-inflammatory effects of thioredoxin reductase inhibition in alveolar macrophages

Sara Staples,Stephanie B. Wall,Rui Li,Trent E. Tipple

Life Sciences（2020）

引用 7|浏览7

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摘要

•Txnrd1 inhibition elicits antioxidant and anti-inflammatory effects.•Txnrd1 inhibition elicits increases in Nrf2 activation and increases GSH contents.•AFN attenuates LPS-induced increases in IL-1β in murine lung macrophages.•The anti-inflammatory and antioxidant effects of are not altered by Se deficiency.

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关键词

Auranofin,Thioredoxin,Thioredoxin reductase,Selenium,Prematurity,Macrophage,Interleukin-1β

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