Anti-Markovnikov Hydroamination Of Racemic Allylic Alcohols To Access Chiral Gamma-Amino Alcohols
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2020)
摘要
A ruthenium-catalyzed formal anti-Markovnikov hydroamination of allylic alcohols for the synthesis of chiral gamma-amino alcohols is presented. Proceeding via an asymmetric hydrogen-borrowing process, the catalysis allows racemic secondary allylic alcohols to react with various amines, affording enantiomerically enriched chiral gamma-amino alcohols with broad substrate scope and excellent enantioselectivities (68 examples, up to >99 %ee).
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关键词
allylic alcohol, amino alcohol, asymmetric catalysis, hydrogen borrowing, ruthenium catalyst
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