Ga-68-Fapi Pet/Ct In Assessment Of Leptomeningeal Metastases In A Patient With Lung Adenocarcinoma

We presented a case of 64-year-old woman with pathologically diagnosed lung adenocarcinoma. Brain metastases were highly suspected due to the appearance of neurological symptoms. However, no abnormal finding in the brain was observed on F-FDG PET/CT. Contrast-enhanced MRI showed the presence of leptomeningeal metastases but with a negative cerebrospinal fluid analysis. For this reason, the patient underwent Ga-FAPI PET/CT, later fused with MRI scans that showed intense uptake of Ga-FAPI in leptomeningeal regions correspondent to the sites of gadolinium enhancement. This case highlights that Ga-FAPI would be promising for the identification of leptomeningeal involvement in patients with malignant disease.