Evidence of altered salivary cytokine concentrations in Rett syndrome and associations with clinical severity

Breanne J. Byiers,Alyssa M. Merbler,Chantel C. Barney,Kristin A. Frenn,Angela Panoskaltsis-Mortari,Michael J. Ehrhardt,Timothy J. Feyma,Arthur A. Beisang,Frank Symons

Brain, Behavior, & Immunity - Health（2020）

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摘要

•Immune dysregulation may play a role in the development of Rett syndrome (RTT), a disorder caused by mutations of the MECP2 gene.•Concentrations of several salivary cytokines were increased in RTT compared to controls.•These same cytokines showed significant positive correlations with clinical severity scores.•Results suggest that salivary cytokines may be a possible indicator of immune dysregulation in RTT.

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关键词

Rett syndrome,MECP2,Cytokines,Saliva,Biomarkers

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