Umbilical cord mesenchymal stromal cells engraft and transdifferentiate into cardiomyocyte-like cells following acute myocardial ischemia⋆.

Zeynep Yigman,Elif Derya Ozdemir,Nilufer N Turan,A Tulga Ulus,Alp Can

Acta Histochemica（2020）

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摘要

•hUC-MSCs treatment following acute MI decreases scar size.•hUC-MSCs treatment improves the left ventricular functions.•hUC-MSCs engraft and contribute to healing process of myocardium after acute MI.•Engrafted hUC-MSCs de novo express cardiomyogenic proteins.

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关键词

α-SA,Calcein-AM,cTnI,cTnT,Cy3,Cy5,D-PBS,Echo,EDTA,F-actin,HF,HGF,HLA,hUC-MSCs,IHC,IV,LAD,LV,LVEDD,LVEF,LVESD,MHC,MI,M-mode,MSCs,P3,PBS,PFA,PVCs,TTC,VEGF,vWF

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