Facilitatory and inhibitory role of central amylin administration in the regulation of the gonadotropin-releasing hormone pulse generator activity in goats

Neuroscience Letters(2020)

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摘要
•Pulsatile GnRH secretion is necessary to maintain reproductive functions.•CTR signaling is associated with the regulation of GnRH pulses.•Activation of CTR had both stimulatory and inhibitory effects on GnRH pulsatility.•Central amylin-CTR signaling modulates the GnRH pulse generator activity.
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关键词
ARC,BST,CTR,DIG,DMH,FITC,GnRH,LH,LV,MBH,MPOA,MUA,OVX,POA,PVN,SCN,SD,VMH
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