A Multifunctional Microfluidic Platform For High-Throughput Experimentation Of Electroorganic Chemistry
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2020)
摘要
Electroorganic synthesis is a promising tool to design sustainable transformations and discover new reactivities. However, the added setup complexity caused by electrodes in the system impedes efficient screening of reaction conditions. Herein, we present a microfluidic platform that enables automated high-throughput experimentation (HTE) for electroorganic synthesis at a 15-microliter scale. Two HTE modules are demonstrated: 1) the rapid electrochemical reaction condition screening for a radical-radical cross-coupling reaction on micro-fabricated interdigitated electrodes, and 2) measurements of kinetics for mediated anodic oxidations using the microliter-scale cyclic voltammetry. The presented modular approach could be deployed for a range of other electroorganic chemistry applications beyond the demonstrated functionalities.
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关键词
electroanalysis, electrosynthesis, flow chemistry, high-throughput experimentation, microfluidics
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