The Interaction Between Energy Intake, Physical Activity And Ucp2-866g/A Gene Variation On Weight Gain And Changes In Adiposity: An Indonesian Nutrigenetic Cohort (Indogenic)

The present study aimed to investigate an interaction between energy intake, physical activity and UCP2 gene variation on weight gain and adiposity changes in Indonesian adults. This is a prospective cohort study conducted in 323 healthy adults living in the city of Yogyakarta, Indonesia. Energy intake, physical activity, body weight, BMI, percentage body fat and waist:hip ratio (WHR) were measured at baseline and after 2 years while UCP2 -866G/A gene variation was determined at baseline. We reported that after 2 years subjects had a significant increment in body weight, BMI, body fat and reduction in WHR (all P < 0 center dot 05). In all subjects, total energy intake was significantly correlated with changes in body weight (beta = 0 center dot 128, P = 0 center dot 023) and body fat (beta = 0 center dot 123, P = 0 center dot 030). Among subjects with the GG genotype, changes in energy intake were positively correlated with changes in body weight (beta = 0 center dot 232, P = 0 center dot 016) and body fat (beta = 0 center dot 201, P = 0 center dot 034). These correlations were insignificant among those with AA + GA genotypes (all P > 0 center dot 05). In summary, we show that UCP2 gene variation might influence the adiposity response towards changes in energy intake. Subjects with the GG genotype of UCP2 -866G/A gene were more responsive to energy intake, thus more prone to weight gain due to overeating.