Acetylase inhibitor SI-2 is a potent anti-inflammatory agent by inhibiting NLRP3 inflammasome activation

Liping Liu,Xueming Xu,Ningjie Zhang,Yening Zhang,Kai Zhao

International Immunopharmacology（2020）

引用 9|浏览10

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摘要

•SI-2 specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.•SI-2 inhibits NLRP3 inflammasome activation in THP-1 cells.•SI-2 blocks the ASC speck formation by interrupting the interaction between NLRP3 and ASC.

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关键词

SI-2,NLRP3 inflammasome,ASC speck

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