Hepatitis B core antigen-based vaccine demonstrates cross-neutralization against heterologous North American Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-2) strains

Yi Lu,Frank Gillam,Qian M Cao,Amy Rizzo,X J Meng,Chenming Zhang

Journal of Virological Methods（2020）

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摘要

•The hepatitis B core antigen was used in a vaccine strategy for porcine reproductive and respiratory syndrome virus.•PRRSV vaccines elicited epitope specific immune response.•A vaccine construct elicited neutralizing antibodies to the homologous and a heterologous virus strain.•A vaccine construct demonstrated cell-mediate immune activity.

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关键词

VLP,HBcAg,PRRSV,Epitope,Vaccine,Heterologous viral neutralization

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