Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology.

Oroxylum indicum(O. indicum) is an important traditional Chinese medicine that exerts a wide spectrum of pharmacological activities. However, the pharmacological effect ofO. indicumand its mechanism of action have not to be systematically elucidated yet. In this study, the druggability for active compounds ofO. indicumwas assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential drug targets ofO. indicumwere identified using PharmMapper database. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed via WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view. Our findings revealed thatO. indicumhas extremely superb druggability with 41 putative identified target genes. GO, KEGG, and network analyses showed that these targets were associated with inflammatory immunoreactions, cancer, and other biological processes. In summary,O. indicumis predicted to target multiple genes/proteins and pathways that shape a network which can exert systematic pharmacological effects.