The Characterization of OXA-232 Carbapenemase-Producing ST437 Klebsiella pneumoniae in China.

Carbapenem-resistant Klebsiella pneumoniae(CRKP) was epidemic around the world and become a global threat to public health. The most important carbapenem-resistant mechanism is producing carbapenemases, especiallyKlebsiella pneumoniaecarbapenemase (KPC), which is prevalent in the international clonal complex CC11. The high-risk multidrug-resistant CC11 is widespread worldwide, and KPC-producing and (New Delhi metallo) NDM-producing strains had been reported in this clonal complex before; moreover, cases with the CC11 strain faced more severe forms of drug resistance and treatment challenges than other clonal complexes. In this study, we identified an OXA-232-producing ST437Klebsiella pneumoniaeisolate in China, which belonged to CC11. The isolate was resistant to beta-lactams, aminoglycosides, and fluoroquinolones but susceptible to fosfomycin, tigecycline, and colistin. The bla(OXA-232) gene was located on a 6141 bp ColKP3-type nonconjugative plasmid, and the plasmid was transformed by chemical transformation successfully. This is the first report of OXA-232-producing ST437K. pneumoniaein China, a new clone of high-risk multidrug-resistant CC11.