The lymphocyte populations and their migration into the central nervous system in tick-borne encephalitis.

Sambor Grygorczuk,Joanna Osada,Kacper Toczyłowski,Artur Sulik,Piotr Czupryna,Anna Moniuszko-Malinowska,Maciej Kondrusik,Renata Świerzbińska,Justyna Dunaj,Sławomir Pancewicz,Milena Dąbrowska

Ticks and Tick-borne Diseases（2020）

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摘要

•Cerebrospinal fluid B lymphocytes associate with tick-borne encephalitis severity.•Th cell count associates with the altered mental status but not neurologic deficits.•The theorized immunopathogenic role of Tc cells is not clinically apparent.•Double-positive T CD4+CD8+ lymphocytes may be protective in viral neuroinfections.•CCL5/CCR5 axis participates in Tc and, to a lesser extent, Th cell migration in TBE.

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关键词

AM,BBB,CNS,CSF,G-CSF,IFN,IL,JE,JEV,M,ME,MEM,TBE,TBEV,WNE,WNV

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