Hiv Coinfection Is Associated With Low-Fitness Rpob Variants In Rifampicin-Resistant Mycobacterium Tuberculosis
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY(2020)
摘要
We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.
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关键词
HIV-TB coinfection, Mycobacterium tuberculosis, drug resistance, fitness cost, rifampicin
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