BNIP3 deletion ameliorated enterovirus 71 infection-induced hand, foot and mouth disease via inhibiting apoptosis, autophagy, and inflammation in mice

Lei Zhu,Xiuwei Hao,Junhua Cao,Xiaodong Xie,Haijun Wang

International Immunopharmacology（2020）

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摘要

•BNIP3 deletion improved EV 71 infection-induced hand, foot and mouth disease.•BNIP3 knockdown attenuated inflammation in hand, foot and mouth disease mice.•BNIP3 deletion inhibited apoptosis in hand, foot and mouth disease mice.•BNIP3 knockdown ameliorated autophagy in hand, foot and mouth disease mice.

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关键词

Bcl2/adenovirus E1B protein-interacting protein 3,Enterovirus 71,Hand, foot and mouth disease,Inflammation,Apoptosis,Autophagy

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