Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity

Lauren Y Sandeman, Wan Xian Kang,Xuemin Wang,Kirk B Jensen,Derick Wong,Tao Bo,Ling Gao,Jiajun Zhao,Christopher D Byrne,Amanda J Page,Christopher G Proud

Molecular Metabolism（2020）

引用 19|浏览27

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摘要

•Knockout of MNK1/MNK2 protects mice against diet-induced obesity.•MNK1/2 DKO mice have higher energy expenditure.•MNK1/2 DKO increases the expression of genes of lipid and mitochondrial metabolism.•Pharmacological inhibition of MNKs has similar effects.

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关键词

Adipose tissue,Diet-induced obesity,MNK,Lipid metabolism,Mitochondria,Energy expenditure

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