On the Programmatic Generation of Reproducible Documents

Reproducible document standards, like R Markdown, facilitate the programmatic creation of documents whose content is itself programmatically generated. While programmatic content alone may not be sufficient for a rendered document since it does not include prose (content generated by an author to provide context, a narrative, etc.) programmatic generation can provide substantial efficiencies for structuring and constructing documents. This paper explores the programmatic generation of reproducible documents by distinguishing components that can be created by computational means from those requiring human-generation, providing guidelines for the generation of these documents, and identifying a use case in clinical trial reporting. These concepts and use case are illustrated through the listdown package for the R programming environment, which is is currently available on the Comprehensive R Archive Network.