Ghrelin protects dopaminergic neurons against MPTP neurotoxicity through promoting autophagy and inhibiting endoplasmic reticulum mediated apoptosis.

Huiqing Wang,Shanshan Dou,Junge Zhu,Ziqi Shao,Chunmei Wang,Baohua Cheng

Brain Research（2020）

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摘要

•Ghrelin protected dopaminergic neurons against MPTP neurotoxicity.•Ghrelin regulated α-synuclein activities induced by MPTP in the SNpc and STR.•Ghrelin promoted the level of autophagy.•Ghrelin inhibited the ERS-mediated apoptosis including IRE1α and Caspase-12 signaling pathway.

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关键词

Ghrelin,Parkinson’s disease,1-Methyl-4-phenyl-1,2,3,6-tetrahydropyran (MPTP),α-Synuclein,Autophagy,Endoplasmic reticulum stress

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