The role of thrombospondin-1 in the pathogenesis of antiphospholipid syndrome

M Patsouras, E Tsiki, P Karagianni,P G Vlachoyiannopoulos

Journal of Autoimmunity（2020）

引用 5|浏览17

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摘要

•Thombospondin-1 (TSP-1) is elevated in patients with Antiphospholipid syndrome.•Patients with both arterial and venous thrombosis have the highest TSP-1 values.•anti-β2GPI-IgG, β2GPI and CXCL4 induce TSP-1 secretion from platelets and HUVECs.•TSP-1 silencing in HUVECs reduces SELE upon anti-β2GPI-IgG-β2GPI-CXCL4 activation.

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关键词

Antiphospholipid,Thrombospondin,Endothelial,Platelets,Monocytes

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