Quantification of surface composition and surface structure of inhalation powders using TOF-SIMS

Mark Nicholas,Mats Josefson,Magnus Fransson,Jonas Wilbs,Carl Roos,Catherine Boissier,Kyrre Thalberg

International Journal of Pharmaceutics（2020）

引用 14|浏览13

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摘要

•Quantification of surface coverage of inhalation powders demonstrated.•Quantification of surface chemical structure of inhalation powders demonstrated.•PRUV® coats lactose carrier as completely but more thinly than MgSt.•2% salbutamol sulfate coats lactose carrier completely using high shear mixing.

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关键词

Imaging,Surface quantification,Inhalation,Dry powders,TOF-SIMS,XPS,Multivariate analysis

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