Protective effect of Hydroxysafﬂor Yellow A on cerebral ischemia reperfusion-injury by regulating GSK3β-mediated pathways

Xiaomei Yang,Lin Chen,Yun Li,Feng Gao,Zhibo Yan,Peng Zhang,Jianbo Wu,Huanliang Wang,Baozhu Sun

Neuroscience Letters（2020）

引用 13|浏览6

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摘要

•HSYA reduces neuro-inflammation through the GSK-3β/NF-κB-mediated inflammatory pathway in MCAO rat model.•HSYA protects neuro-apoptosis through caspase-3-mediated apoptosis pathway in MCAO rat model.•HSYA alleviates GSK3β/caspase-3 apoptotic pathway in OGD-challenged neurons apoptotic cells.

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关键词

HSYA,I/R injury,MCAO,OGD,ROS,GSK-3,eNOS,NO,PGC-1α,NOS,iNOS

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