Revealing the mechanisms and the material basis of Rubia cordifolia L. on abnormal uterine bleeding with uniting simultaneous determination of four components and systematic pharmacology approach-experimental validation.

Kan Wang,Lan Gao,Qiao Zhang,Yi Zhang,Weifeng Yao,Min Zhang,Yuping Tang,Anwei Ding,Li Zhang

Journal of Pharmaceutical and Biomedical Analysis（2020）

引用 6|浏览19

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摘要

•A novel method for simultaneous determination of quinones in Rubia cordifolia L was developed.•Rubia cordifolia L. could improve fibrinolysis system by inhibiting HIF-1/PAI-1.•Rubia cordifolia L. could improve arachidonic acid metabolism by inhibiting COX-2 and cPLA2.•Mollugin played an important in role Rubia cordifolia L for treating abnormal uterine bleeding.

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关键词

Rubia cordifolia L.,Abnormal uterine bleeding,Systematic pharmacology,Mollugin

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