Tmem216 Deletion Causes Mislocalization Cone Opsin And Rhodopsin And Photoreceptor Degeneration In Zebrafish

Our results indicate that TMEM216 is essential for normal genesis of outer segment disc structures, transport of outer segment materials, and survival of photoreceptors in zebrafish. These tmem216 knockout zebrafish will be useful in studying how transition zone proteins regulate photoreceptor outer segment formation and maintenance.