Use Of Drug-Level Testing And Single-Genome Sequencing To Unravel A Case Of Human Immunodeficiency Virus Seroconversion On Pre-Exposure Prophylaxis

Matthew A Spinelli, Brentton Lowery, Jennifer A Shuford, Jon Spindler,Mary F Kearney, Jenny R McFarlane,Cheryl McDonald,Hideaki Okochi,Nhi Phung,Karen Kuncze, Kathryn Jee, DeeJay Johannessen,Peter L Anderson,Dawn K Smith,Patricia Defechereux,Robert M Grant,Monica Gandhi

CLINICAL INFECTIOUS DISEASES（2021）

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摘要

Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.

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关键词

PrEP, HIV seroconversion, adherence, single-genome-sequencing, PrEP failure

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