Decitabine induction with myeloablative conditioning and allogeneic hematopoietic stem cell transplantation in high-risk patients with myeloid malignancies is associated with a high rate of infectious complications.

Christopher R D'Angelo, Aric Hall, Kaitlin M Woo,KyungMann Kim,Walter Longo,Peiman Hematti,Natalie Callander,Vaishalee P Kenkre,Ryan Mattison,Mark Juckett

Leukemia Research（2020）

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摘要

•Decitabine plus myeloablative allogeneic transplant was studied in myeloid cancers.•Phase II clinical trial did not meet hypothesized improvement in overall survival.•Decitabine and myeloablative combo led to high rates of infection and mortality.•High rates of neutropenia and immunosuppression was the likely cause of infections.

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关键词

Decitabine,High-risk myeloid disease,Allogeneic hematopoietic stem cell transplant,Clinical trial,Infection,Immunosuppression

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