Graphs of dynamic H-bond networks: from model proteins to protein complexes in cell signaling

•Networks of dynamic hydrogen bonds, which for membrane proteins can include lipids, shape protein conformational energy landscapes..•Graph-based algorithms allow us to identify protein groups with central role in protein H-bond networks.•H-bond networks that include proton binding sites or proton antenna clusters could enable pH sensing.•Membrane proteins involved in cell signaling have extensive H-bond networks, which could contribute to pH sensitivity.