Machine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma
NATURE COMMUNICATIONS(2020)
摘要
Early cancer detection greatly increases the chances for successful treatment, but available diagnostics for some tumours, including lung adenocarcinoma (LA), are limited. An ideal early-stage diagnosis of LA for large-scale clinical use must address quick detection, low invasiveness, and high performance. Here, we conduct machine learning of serum metabolic patterns to detect early-stage LA. We extract direct metabolic patterns by the optimized ferric particle-assisted laser desorption/ionization mass spectrometry within 1 s using only 50 nL of serum. We define a metabolic range of 100–400 Da with 143 m/z features. We diagnose early-stage LA with sensitivity~70–90% and specificity~90–93% through the sparse regression machine learning of patterns. We identify a biomarker panel of seven metabolites and relevant pathways to distinguish early-stage LA from controls ( p < 0.05). Our approach advances the design of metabolic analysis for early cancer detection and holds promise as an efficient test for low-cost rollout to clinics.
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关键词
Biomedical engineering,Cancer metabolism,Mass spectrometry,Tumour biomarkers,Science,Humanities and Social Sciences,multidisciplinary
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