Dopamine D 2 receptor supersensitivity in the hypothalamus of olfactory bulbectomized mice.

Kohei Takahashi,Osamu Nakagawasai,Takeharu Nakajima,Myu Okubo,Yuki Nishimura,Wakana Sakuma,Ryota Yamagata,Wataru Nemoto,Kazuya Miyagawa,Kazuhiro Kurokawa,Atsumi Mochida-Saito,Minoru Tsuji,Hiroshi Takeda,Takeshi Tadano,Koichi Tan-No

Brain Research（2020）

引用 5|浏览21

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摘要

•Sulpiride reversed apomorphine-induced hypothermic response in OBX mice.•SCH23390 and SB277011A failed to reverse apomorphine-induced hypothermia.•OBX mice exhibited significantly enhanced quinelorane-induced hypothermia.•OBX mice showed reduced in TH and p-DARPP-32 levels in the hypothalamus.•OBX mice showed increased D2DR in the hypothalamus.

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关键词

ANOVA,AUC,CPu,DA,DARPP-32,D2DR,ECL,HPA axis,i.p.,NAcC,NAcSh,OBX,p-,s.c.,SEM,TBST,TH

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