Enhanced prognostic stratification of neoadjuvant treated lung squamous cell carcinoma by computationally-guided tumor regression scoring

•Histological residual tumor burden after neoadjuvant chemotherapy is an important prognosticator for NSCLC.•Computationally assessed histological residual tumor parameters correlate with metabolic response assessed by FDG PET/CT.•Residual tumor burden computed in sections with the least regression is an independent prognostic factor.•Residual tumor percentage is the best predictor of survival among other computational parameters.•The proposed computational approach could aid current assessment of tumor regression.