Evaluation of Botulium toxin type A for treating hypertrophic scars: A split-scar, double-blind randomized controlled trial.

Background Hypertrophic scars (HS) are a challenging disorder that mostly develops during wound-healing process following skin injuries. Methods A split-scar, double-blind randomized controlled trial was held to assess the safety and efficacy of botulinum toxin type A (BTA) injection in hypertrophic scars (HS). Thirty patients with old scars (range: 1-15 years) were treated, with sides randomized to receive treatment with either BTA or 0.9% normal saline once monthly for three consecutive months. Scars were assessed using the Vancouver scar scale (VSS) along with digital photograph standardization. Results Twenty-one subjects completed the study. The mean VSS score for the BTA-treated half of the scars decreased from 7.29 +/- 2.327 before injection to 5.33 +/- 2.41 following injection which was highly significant (P = .01). For the control half, the mean VSS decreased insignificantly from 7.29 +/- 2.327 before injection to 7.10 +/- 2.234 following injection (P = .104). Conclusion Clinical and cosmetic improvement was demonstrated significantly among the BTA-treated group. BTA can be an additional and useful tool for improving scar outcomes.