A Retrospective Comparison of DLI and gDLI for Post-Transplant Treatment.

Donor lymphocyte infusion (DLI) is used to prevent or treat haematological malignancies relapse after allogeneic stem cell transplantation (allo-SCT). Recombinant human granulocyte colony-stimulated factor primed DLI (gDLI) is derived from frozen aliquots of the peripheral blood stem cell collection. We compared the efficacy and safety of gDLI and classical DLI after allo-SCT. We excluded haploidentical allo-SCT. Initial diseases were acute myeloblastic leukaemia (n= 45), myeloma (n= 38), acute lymphoblastic leukaemia (n= 20), non-Hodgkin lymphoma (n= 10), myelodysplasia (n= 8), Hodgkin lymphoma (n= 8), chronic lymphocytic leukaemia (n= 7), chronic myeloid leukaemia (n= 2) and osteomyelofibrosis (n= 1). Indications for DLI were relapse (n= 96) or pre-emptive treatment (n= 43). Sixty-eight patients had classical DLI and 71 had gDLI. The response rate was 38.2%, the 5-year progression-free survival (PFS) rate was 38% (29-48) and the 5-year overall survival (OS) rate was 37% (29-47). Graft versus host disease rate was 46.7% and 10.1% of patients died from toxicity. There were no differences between classical DLI and gDLI in terms of response (p= 0.28), 5-year PFS (p= 0.90), 5-year OS (p. 0.50), GvHD (p= 0.86), treated GvHD (p= 0.81) and cause of mortality (p. 0.14). In conclusion, this study points out no major effectiveness or toxicity of gDLI compared to classical DLI.