Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland
INFECTION(2020)
摘要
Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS -mutant Candida albicans / glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15–77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.
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关键词
glabrata,echinocandin-resistant
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