Fabrication Of Piezoelectric Porous Batio(3)Scaffold To Repair Large Segmental Bone Defect In Sheep

JOURNAL OF BIOMATERIALS APPLICATIONS(2020)

引用 22|浏览7
暂无评分
摘要
Porous titanium scaffolds can provide sufficient mechanical support and bone growth space for large segmental bone defect repair. However, they fail to restore the physiological environment of bone tissue. Barium titanate (BaTiO3) is considered a smart material that can produce an electric field in response to dynamic force. Low-intensity pulsed ultrasound stimulation (LIPUS), as a kind of micromechanical wave, can not only promote bone repair but also induce BaTiO(3)to generate an electric field. In our studies, BaTiO(3)was coated on porous Ti6Al4V and LIPUS was externally applied to observe the influence of the piezoelectric effect on the repair of large bone defects in vitro and in vivo. The results show that the piezoelectric effect can effectively promote the osteogenic differentiation of bone marrow stromal cells (BMSCs) in vitro as well as bone formation and growth into implants in vivo. This study provides an optional alternative to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and osseointegration for the repair of large bone defects.
更多
查看译文
关键词
Bone defect, barium titanate, low-intensity pulsed ultrasound, porous scaffold, osteogenesis
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要