Endocrine and Metabolic Dysfunction During Aging and Senescence Leucine-rich repeat kinase-1 regulates osteoclast function by modulating RAC 1 / Cdc 42 Small GTPase phosphorylation and activation

Canjun Zeng,* Helen Goodluck,* Xuezhong Qin, Bo Liu, Subburaman Mohan, and Weirong Xing Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Affairs Medical Center, Loma Linda, California; Department of Medicine, Loma Linda University, Loma Linda, California; Department of Orthopedics, The Third Affiliated Hospital Of Southern Medical University, Guangzhou, China; Department of Orthopedics, The Third Xiangya Hosptial, Central South University, Changsha, Hunan, China