PP.LB02.04: GLOMERULAR PROTECTIVE EFFECT AND PANCREATIC PRESERVATION INDUCED BY EMPAGLIFLOZIN TREATMENT IN COHEN ROSENTHAL DIABETIC HYPERTENSIVE RATS

According to the classical pattern: the presence of albuminuria (ACC > 30 mg/g) is associated with nondipper/riser pattern:(45.7% nondipper/riser vs. 20% dipper, p < 0.05).No differences were found in both groups in terms of BMI nor ongoing treatment with ACE inhibitors and ARBs. According to NHBP pattern yes/no: the presence NHBP is associated with higher prevalence of albuminuria(46%) compared with the absence of NHBP (16,1%;p < 0.05). Moreover patients with NHBP have a higher BMI than patients that do not have NHBP (75%vs.55.3%;p < 0.05). BMI was not a confounding factor, which is proven by the fact that 100% of patients with BMI < 25 presented albuminuria(p < 0.05). Regarding patients with BMI < 25,100% of the patients with NHBP presented albuminuria and only 28.6% of patients with non-dipper/riser pattern presented albuminuria.