SYNTHESIS OF a-CYANOACRYLATES SOLVENT FREE CONDITIONS AND THEIR ANTIMICROBIAL ACTIVITY

Recently, it was found that some α-cyanoacrylates prepared from Knoevenagel condensation are found to be biologically active against some strain of bacteria (Chin Knoevenagel reaction is the condensation reaction between aldehydes and compounds containing active methylene to generate alkene. It was first discovered by Emil Knoevenagel in 1896 (Knoevenagel, 1894). Different catalysts for Knoevenagel condensation (KC) employed so far include triphenylphosphine and Potassium fluoride mixture (Se al., 2002)carried out using bases or acids in the presence of organic solvents the mainly DMAP (Narsaiah Generally KC reactions are catalyzed with weak organic bases like Pyridine (Li, 1999), pyrrolidine (Borhegyi, 2010) and tertiary amine. Several Inorganic salts such as ZnCl Rao and Venkataratnam, 1991), Zinc acetate and zinc bromide are also employed (Jiang et al., 2009). Since then it has gained great importance in organic synthesis as one of the key C=C formation reaction. Such types of Alkenes formed through Knoevenagel condensation possess wide variety of biological applications. Some of derivatives form by KC are used for diagnosis of disease like Alzheimer with the assistance of