Role of Pentraxin 3 in Lupus Nephritis

Systemic lupus erythematosus is a complex, multisystem autoimmune disease characterized by production of high-titer autoantibodies directed against ubiquitously expressed selfantigens. The roles of pentraxins 3, dysregulated apoptosis and deficient clearance of apoptotic material in SLE have attracted much attention. Aim of the Work: To find a role of pentraxin 3 in lupus erythematosus activity. Patients and Methods: Our study was conducted on 40 female SLE nephritis patients aged (18-40y) with activity. Disease activity was determined by the SLE disease activity index (SLEDAI). All the patients were under ttt with non steroidal therapy and they did not receive immuno suppressive therapy, and 20 healthy female age matched subjects served as control. All were collected from in patient Kasr El Aini Hospital. All were subjected to full clinical evaluation, CBC, 24h urinary protein, renal biopsy for SLE nephritis staging, ANA, anti ds DNA, ESR, and serum level of pentraxin 3. Results: It was found that serum level of pentraxin is significantly lower in patients than control p-value 0.0001. We also found that pentraxin was -vely correlated with ESR (p-0.05), but not correlated with 24h urinary albumin p-value >0.05. Conclusion: Pentraxin 3 deficiency may have a role in SLE renal activity.