Therapeutic Efficacy of Multimineral Injection to Treat Leukoderma in Buffaloes

Leukoderma or vitiligo is common depigmenting skin disorder characterized by acquired, idiopathic, progressive, circumscribed hypomelanosis of the skin and hair. According to Radostitis et al., (2007) leukoderma is the patchy dipigmentation of skin with premature graying of local hairs with the usual manifestation as appearance of patches of gray or white hair. According to Cerundolo et al., (1991) in buffalo there is depigmentation that affects skin melanocytes. Im et al., (1994) defined leukoderma as a pigmentry disorder of unknown cause characterized by depigmented patches due to destruction of melanocyte. Many theories (biochemical theory, cytotoxic theory, oxidant-antioxidant theory, neural theory, viral theory, autoimmune theory, self-destruct theory, growth factor theory and convergence theory) have been proposed to explain this (Kaur Navneet et al., 2012). Causative factors of leukoderma may include environmental insult (Cumming & Nordlund, 1995), autoimmune response in which melanocytes are destroyed by immune system (Fishman et al., 1997), and inherited predisposition and/or copper deficiency (Panduranga Rao et al., 2002). Kumar et al., (2007) observed distinct areas of depigmentation (Achromotrichia) and localized alopecia of skin on both left and right side of neck, thorax, medial aspect of International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7692 Special Issue-7 pp. 249-254 Journal homepage: http://www.ijcmas.com