Cardiac function and heart failure urine 8-hydroxy-2 ’-deoxyguanosine is a marker for predicting mortality and morbidity

Background: Oxidative stress is known to play a crucial role in the pathogenesis of heart failure. In our preliminary study, the level of serum 8-hydroxy-2’-deoxyguanosine (8-OHdG: ng/ml), a product of oxidative DNA damage, was higher in coronary sinus than in aorta in CHF, while it was not in normal subjects, indicating that reactive oxygen species is produced in failing cardiac tissue. Based on these findings, we hypothesized that urine (U)-8-OHdG might be a useful biomarker for predicting the prognosis and evaluating the response to the treatment with beta-blocker in patients with CHF.