Blockade of Migration inhibitory factor-CD 74 signalling on 1 macrophages and dendritic cells restores the anti-tumour immune 2 response against metastatic melanoma . 3

32  Mounting an effective immune response against cancer requires the activation of innate and adaptive 33 immune cells. Metastatic melanoma is the most aggressive form of skin cancer. While 34 immunotherapies have shown a remarkable success in melanoma treatment, patients develop 35 resistance by mechanisms that include the establishment of an immune suppressive tumour 36 microenvironment. Thus, understanding how metastatic melanoma cells suppress the immune system 37