The Impact of ESCRT on A b 1 � 42 Induced Membrane Lesions in a Yeast Model for Alzheimer ’ s Disease

Fruhmann G, Marchal C, Vignaud H, Verduyckt M, Talarek N, De Virgilio C, Winderickx J and Cullin C (2018) The Impact of ESCRT on A 1 42 Induced Membrane Lesions in a Yeast Model for Alzheimer’s Disease. Front. Mol. Neurosci. 11:406. doi: 10.3389/fnmol.2018.00406 The Impact of ESCRT on Ab1 42 Induced Membrane Lesions in a Yeast Model for Alzheimer’s Disease Gernot Fruhmann1†, Christelle Marchal2†‡, Hélène Vignaud2, Mathias Verduyckt1, Nicolas Talarek3, Claudio De Virgilio4, Joris Winderickx1* and Christophe Cullin2* 1 Functional Biology, KU Leuven, Leuven, Belgium, 2 Institut de Chimie et Biologie des Membranes et des Nano-objets, University of Bordeaux, CNRS UMR 5248, Pessac, France, 3 Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France, 4 Department of Biology, Université de Fribourg, Fribourg, Switzerland Ab metabolism plays a pivotal role in Alzheimer’s disease. Here, we used a yeast model to monitor Ab 42 toxicity when entering the secretory pathway and demonstrate that